Abstract
Unsymmetrical thioureas and thiosemicarbazides, valuable as lead compounds for antitubercular drug design and discovery, are prepared by the reactions of isothiocyanates with aromatic amines and acid hydrazides, respectively, in robust procedures that permit considerable structural variety. Occasional isolation of symmetrical thioureas derived wholly from the isothiocyanate components of these reactions may occur by thermal fragmentation of the initial thioureidation products.
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