Abstract
The proportion of individuals with bladder cancer has drastically increased, thereby rendering bladder cancer a focus of social concern and great challenge for human health management. Hydrogels with three-dimensional network structures have attracted considerable attention in the field of drug delivery for tumor therapy. Therefore, exploring hydrogel drug-delivery systems with excellent biocompatibility and targeting ability is a current research hotspot. Herein, a chitosan/dialdehyde sodium alginate/magnetic dopamine hydrogel was investigated for this purpose. The hydrogel was prepared from chitosan using sodium dialdehyde alginate and dopamine via grafting, crosslinking, and compounding. Furthermore, characterization of the product structure, targeted adhesion, and evaluation of drug delivery properties were performed. The prepared wall-adherent hydrogel materials exhibited excellent targeted drug-delivery and controlled-release properties. In addition, the effect of dopamine dosage on the performance of drug-loaded hydrogels was examined. In conclusion, the drug-delivery materials exhibited strong organ-wall adhesion, hydrogel properties, targeting ability, antibacterial and antimicrobial abilities (98%), and biocompatibility (99%). Based on these excellent properties, the constructed targeted hydrogels demonstrate considerable potential for drug delivery and bladder cancer treatment.
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