Abstract
In this study, the porous composite films of carboxymethyl chitosan/alginate/tranexamic acid were fabricated, with calcium chloride as the crosslinking agent and glycerin as a plasticizer. The composite films were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The properties of the composite films, including water absorption, air permeability, and cumulative release rate, were tested. In addition, their hemostatic performance was evaluated. The results showed that the appearance of the films with good adhesion was smooth and porous. FTIR showed that chemical crosslinking between carboxymethyl chitosan and sodium alginate was successful. The excellent cumulative release of tranexamic acid in the composite films (60–80%) gives the films a significant procoagulant effect. This has good prospects for the development of medical hemostasis materials.
Highlights
The skin is the first barrier of the human body for defense against external stimuli and damage.Damage caused by mechanical factors can lead to microbial invasion, to loss of protein, water, and blood volume, and even to death [1,2]
The development of excellent films for skin trauma and rapid hemostasis is key to treatment, which is closely related to human health [3]
Carboxymethyl chitosan/sodium alginate/tranexamic acid composite films were successfully prepared by a freeze-drying method
Summary
The skin is the first barrier of the human body for defense against external stimuli and damage.Damage caused by mechanical factors can lead to microbial invasion, to loss of protein, water, and blood volume, and even to death [1,2]. The development of excellent films for skin trauma and rapid hemostasis is key to treatment, which is closely related to human health [3]. Owing to its excellent biocompatibility, biodegradability, non-toxicity, and various physiological functions such as hemostasis, bacteriostatic, anti-cancer, and lipid-lowering [5,6], chitosan has been extensively used in biomedicine. Due to the coexistence of -NH2 and -COOH, CMCS has better biocompatibility, moisture absorption, antibacterial, and film-forming properties compared to chitosan [8,9]. As a natural wound repairing material, sodium alginate has good thickening, flocculation, and chelating properties [10]. Due to its unique film-forming properties and non-toxic degradability, it is widely used as a gel film and clinical medical dressing which has healing effects on burns, piercing wounds, and deep ulcer bleeding [11,12]. Its structure is similar to that of lysine, which inhibits the cleavage of fibrin
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