Abstract
In this study, the separation properties of Polyvinylidene fluoride (PVDF) hollow fiber hemodialysis membranes were improved by optimizing membrane morphology and structure. The results showed that the PVDF membrane had better mechanical and separation properties than Fresenius Polysulfone High-Flux (F60S) membrane. The PVDF membrane tensile stress at break, tensile elongation and bursting pressure were 11.3 MPa, 395% and 0.625 MPa, respectively. Ultrafiltration (UF) flux of pure water reached 108.2 L∙h−1∙m−2 and rejection of Albumin from bovine serum was 82.3%. The PVDF dialyzers were prepared by centrifugal casting. The influences of membrane area and simulate fluid flow rate on dialysis performance were investigated. The results showed that the clearance rate of urea and Lysozyme (LZM) were improved with increasing membrane area and fluid flow rate while the rejection of albumin from bovine serum (BSA) had little influence. The high-flux PVDF dialyzer UF coefficient reached 62.6 mL/h/mmHg. The PVDF dialyzer with membrane area 0.69 m2 has the highest clearance rate to LZM and urea. The clearance rate of LZM was 66.8% and urea was 87.7%.
Highlights
Hemodialysis (HD) is a relatively safe purification technique for curing renal failure
The Polyvinylidene fluoride (PVDF) membranes were prepared by non-solvent-induced phase separation (NIPS) method
The casting solution viscosity becomes bigger and bigger with Polyethylene glycol (PEG) molecular weight increasing when PVDF concentration is under certain preconditions, which can decrease the formation of macro voids [20]
Summary
Hemodialysis (HD) is a relatively safe purification technique for curing renal failure. The core element is Ultrafiltration hollow fiber membrane (HFM) [1,2]. The core aim for hemodialysis is to remove “middle” and “small” molecules toxin, such as β2-MG and urea nitrogen. There are more and more polymeric materials in HD to improve the clearance for small molecules and blood compatibility. Polyethersulfone (PES) and polysulfone (PSF) hemodialysis membranes show better biocompatibility, functional effectiveness, and small substances clearance than other membranes; so they are widely used in hemodialysis [3,4,5,6,7]. The clearance for “middle” molecules toxin and
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