Abstract
Hydroxyethylstarch microspheres were prepared using an emulsion-heat denaturation technique. In order to achieve short-term embolization of arteries, several sizes of microparticles were needed and could be adjusted, within the range 25–400 μm, by the speed of agitation during the emulsion step. In vitro, degradation of microspheres in aqueous physiologic medium was preceded by swelling and occurred at rates inversely proportional to the temperature of preparation. In vivo in rabbits, the duration of embolization of the renal artery after selective catheterism also depended on the temperature of microsphere preparation, and could be easily adjusted within the range 5–45 min.
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