Preparation and performance study of Ti-10Mo-28Nb-3Zr-yTa alloys for biomedical application

Abstract

Ti-10Mo-28Nb-3Zr-yTa series biomedical β-Ti alloys were theoretically designed using non-biologically toxic Ta as the additive element of Ti-10Mo-28Nb-3Zr alloy by d-electronic theoretical alloy design method, expecting to obtain a lower elastic modulus and higher strength alloy that matches human bones. The microstructure, mechanical properties, corrosion resistance, osteogenic experiment and cytotoxicity of the alloys were tested and analyzed. The results show that the addition of an appropriate amount of Ta will help stabilize the β phase of the Ti-10Mo-28Nb-3Zr alloy, and at the same time can effectively reduce the alloy's elastic modulus. The mechanical properties test shows that Ti-10Mo-28Nb-3Zr-6Ta alloy has the minimum elastic modulus of 27.59 GPa, and the compressive strength is 635 MPa, which meets the requirements of human bone mechanical properties and can meet the mechanical fit of human bone. The corrosion resistance result shows that Ti-10Mo-28Nb-3Zr-6Ta alloy has good corrosion resistance, its self-corrosion current density is 2.726×10-6 A•cm-2 , self-corrosion voltage is -188.912 mV, and polarization resistance is 1.639×105 Ω•cm -2 . The osteogenesis experiment shows that Ti-10Mo-28Nb-3Zr-4Ta alloy has the best bone-promoting effect. Cytotoxicity evaluation experiment shows that the RGR of Ti-10Mo-28Nb-3Zr-yTa alloys were greater than 70% of the negative control group, indicates that the biological properties of the alloy are very reliable.