Preparation and Optimization of floating microbeads of ciprofloxacin HCl

Abstract

The objective of this work is to generate a gastro retentive sustained release dosage form of a water soluble drug, Ciprofloxacin, from a fully aqueous environment avoiding the utilize of any organic solvent. A new emulsion gelation system is used to arrange emulsion gel beads by sodium alginate as the polymer. The gel beads containing is set up by gently mixing or homogenizing oil and water phase containing sodium alginate which is then extruded in to calcium chloride solution. The effects of factors like concentration of oil, curing time, and drug: polymer ratio, alginate: pectin proportion and therapeutic agent on drug entrapment efficiency, floating lag time, and morphology and drug release are study. Minimizing the curing time of beads leaded to enhanced drug entrapment efficiency. The use of sodium alginate and combinations of sodium alginate and pectin are used to study the effect on the sustaining property of the formed beads. It is found that sodium alginate was not sufficient to uphold the drug release at gastric pH. Instead of it, suitable amalgamation of alginate and pectin could afford the sustain release of drug. The results confirm that these beads can entrap even a water soluble drug as Ciprofloxacin in sufficient amount and also can successfully distribute the drug in stomach for a extend duration of time.