Abstract
Mouse myeloid leukemic M1 cells can be induced to differentiate into macrophages and granulocytes in vitro by a protein inducer (D-factor) in body fluids and conditioned media from various cells and tissues. Antiserum to D-factor was prepared by immunizing a rabbit with D-factor partially purified from conditioned medium of mouse L929 cells. At 1:20 dilution, the antiserum nearly completely suppressed the activities of various D-factor preparations from mice and partially suppressed the activities of preparations from rats and hamsters. It did not cross-react with factors stimulating colony formation of macrophages and granulocytes from normal bone marrow cells.
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