Abstract
The term immunotherapy was introduced by Norman and Lichtenstein6 to designate the treatment of allergic respiratory disease by injections of extracts of vaccines of the antigens responsible for illness. The usage of the term has been extended to similar treatment in the therapy of symptoms owing to certain drug reactions and allergic reactions to insect stings. In practice, immunotherapy consists of the injection of progressively larger amounts of antigen (allergen) until a predetermined dose is reached, symptoms are alleviated, or the patient's tolerance to the injected amount is increased. The intent of this article is to discuss the practical aspects of the preparation of allergen vaccines. No attempt has been made to discuss the mechanisms of action or the efficacy of this form of therapy. This article focuses on vaccines for airborne allergens. The authors discuss the potency of individual vaccines and the factors that may alter potency. In addition, the authors describe standardized allergen vaccines. Practical suggestions are offered for vaccine preparation and storage.
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