Abstract
Indomethacin (IM) sustained release suppositories were prepared by using a solid matrix of cellulose acetate phythalate (CAP) and trimethylamonium methacrylate chloride's (Eudragit RL and RS) as poorly soluble cariers. Witepsol H15 and polyethylene glycol (PEG) mixtures were used as examples of hydrophobic and hydrophilic bases, respectively. Disintegration time, fracture point and release experiments were conducted on the formulations. The results indicate that Eudragit RL/RS (1:1) combination was found more suitable than CAP as a matrix material. From the kinetic assesment of release data, the best fit was achieved with Q t kinetic
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