Abstract
In this report, we designed and synthesized polyacrylonitrile/silver (PAN/AgNPs) nanofibers via an in-situ method to obtain a washable with high-dispersed silver nanoparticles membrane to form the hierarchically organized antibacterial mask to prevent the two-way effect of bacteria from person to environment and environment to person. For this objective, the electrospun PAN nanofibers were stabilized via the heating method. Different amounts of AgNPs were loaded into the PAN nanofibers by using silver nitrate and sodium hydroxide solutions. The basic results showed that AgNPs was homogenously loaded in PAN nanofiber matrixes. Furthermore, the release profile based on two-stage release theory showed that when the negligible amount of AgNPs was loaded into the nanofibers, the release significantly decreased, whereas antibacterial activity increased. The greatest potential antibacterial activity of the lowest amount of AgNPs showed controllable AgNPs release from PAN nanofibers that has a direct relationship with the washability and could promote the application of the produced product.
Highlights
Over the last 50 years, antibiotic resistance has been a major health concern in the world since bacteria progressively adapted to antibiotics [1]
Many antibacterial additives such as phenols, inorganic salts, organometallics [5], organic material like honey [7], and metallic nanoparticles, as well as zinc oxide, titanium oxide [8], and silver nanoparticles (AgNPs) [9] with chemical characteristics [10,11,12] have been used in electrospun nanofibers for wound dressings
Silver nanoparticles among the antibacterial materials showed the greatest potential to be employed in various fields such as biomedical textiles [13] or electronics [14], thanks to their unique properties in electroconductivity and antibacterial activity [15]
Summary
Over the last 50 years, antibiotic resistance has been a major health concern in the world since bacteria progressively adapted to antibiotics [1]. Many antibacterial additives such as phenols, inorganic salts, organometallics [5], organic material like honey [7], and metallic nanoparticles, as well as zinc oxide, titanium oxide [8], and silver nanoparticles (AgNPs) [9] with chemical characteristics [10,11,12] have been used in electrospun nanofibers for wound dressings. Silver nanoparticles among the antibacterial materials showed the greatest potential to be employed in various fields such as biomedical textiles [13] or electronics [14], thanks to their unique properties in electroconductivity and antibacterial activity [15]. The researchers did not focus on the stabilized AgNPs in the nanofiber structures to produce an antibacterial mask by hierarchically organizing the nanofiber membrane to control the AgNPs release by chemical bonding. We attempted to fabricate a polyacrylonitrile/silver (PAN/AgNPs) nanofibers composite membrane for a washable antibacterial mask by the hierarchical arranging of layers. Agar disc diffusion method was chosen for antibacterial activity test
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