Abstract
Magnesium ion substituted biphasic calcium phosphate (Mg‐BCP) bioceramic microscaffolds with spherical and porous morphology were successfully prepared using in situ coprecipitation and rotary spray drying atomization process for application of tissue engineering combined with human adipose tissue‐derived mesenchymal stem cells (hAT‐MSCs). After 4 weeks of immersion in Hanks’ balanced salt solution (HBSS), Mg‐BCP micro‐scaffolds showed the enhanced biodegradation and bioactivity due to the substituted Mg2+ ion present in the BCP structure. In this study, it was observed that hAT‐MSCs have clearly attached on the surface of Mg‐BCP micro‐scaffolds. In addition, Mg‐BCP micro‐scaffolds exhibited the improved biocompatibility and osteoconductivity via in vitro and in vivo biological tests with hAT‐MSCs. Therefore, these bioceramic micro‐scaffolds had potential to be used as hAT‐MSCs microcarriers for biomedical applications.
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