Abstract
AbstractThe purpose of this study is to prepare 99mTc‐diaminoethylpropane diamine haxaacetic acid and clarify its renal excretion mechanism. BPHA obtained from chemical synthesis and characterized by IR and MS was labeled with technitium‐99m. The renal excretion mechanism was determined by probenecid inhibition experiment. The radioactivity remained in the body at different time point postinjection was measured by a γ detector. Renal dynamic imaging of rabbit and human was performed using a γ camera. For all the experiments 99mTc‐DTPA was also examined as contrast. Similar to 99mTc‐DTPA, 99mTc‐BPHA was excreted with a glomerular excretion mechanism. After 24 h, 99mTc‐BPHA remained in the body was very little. Kidney imaging of rabbit and volunteer showed excellent kidney images and fast 99mTc‐BPHA excretion. The results showed that the self‐made 99mTc‐BPHA appeared to be a glomerular filtration imaging agent satisfying clinical requirement and an alternative to 99mTc‐DTPA.
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