Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride

Abstract

Oral controlled drug delivery systems represent the foremost widespread kind of sustained drug delivery systems for the plain blessings of oral route of drug administration. Such systems release the drug with constant or variable unleash rates. The oral controlled release systems show a typical pattern of drug unleash within which the drug concentration is maintained in the therapeutic window for a chronic amount of your time (sustained release), there by guaranteeing sustained therapeutic action. They are used as single dosage form. Present work involves preparation and analysis of sustained release beads of beads of Zolmitriptan Hydrochloride using Sodium alginate as natural polymer as well as Hydroxyl Propyl Methyl Cellulose K15, Chitosan Hydrochloride. The technique employed for preparation of beads of the drug is ionotropic gelation.