Abstract

Ultrasound imaging is a widely used technique in every health care center and hospital. Ultrasound gel is used as a coupling medium in all ultrasound procedures to replace air between the transducer and the patient’s skin, as ultrasound waves have trouble in traveling through air. This research was performed to formulate an inexpensive alternative to commercially available ultrasound gel as it is expensive and imported from other countries. Different formulations with different concentrations of carbopol 980 (CAR 980) and methylparaben were prepared with natural ingredients such as aloe vera gel and certain available chemicals that have no harmful effects on the skin. To justify the efficiency of the formulations; necessary physicochemical characteristics such as visual clarity, homogeneity, transparency, skin irritation, antibacterial activity, pH, stability, spreadability, conductivity, acoustic impedance, viscosity, and cost were evaluated. Moreover, a comparison study was also conducted with commercially available ultrasound gel that was utilized as a control. All samples showed excellent transparency and no microbial growth. S1 was the only formulation that met all of the requirements for commercial ultrasound gel and produced images that were similar to those produced by commercial ultrasound gel. So, this formulation could be used as an alternative to expensive commercial ultrasound gel for taking images in hospitals and medical centers.

Highlights

  • Ultrasonography is an ultrasound-based medical imaging technique that is utilized for mapping or identifying internal aspects of the patient’s body, such as the fetus, muscles, and tendons [1,2,3,4]

  • An inexpensive, optimized, and good quality ultrasound gel was formulated by utilizing carbopol 980, methylparaben and propylparaben, aloe vera gel, glycerine, disodium EDTA, distilled water, and TEA

  • The physicochemical properties of all prepared formulations were evaluated by comparing the results of the prepared formulations to the results of a commercial ultrasound gel available in the market, which was utilized as a control

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Summary

Introduction

Ultrasonography (ultrasound imaging) is an ultrasound-based medical imaging technique that is utilized for mapping or identifying internal aspects of the patient’s body, such as the fetus, muscles, and tendons [1,2,3,4]. Ultrasound procedures are utilized for treating skin conditions such as reducing wrinkles and treatment of warts [2,7,9]. Gels 2022, 8, 42 procedures are utilized for treating skin conditions such as reducing wrinkles and treatment of warts [2,7,9]. Ultrasound fresh aloe vera gel,gel, which doesdoes not not irritate the skin and and makes them safe for people with sensitive skin.

Chemical
Characterization
Homogeneity
UV-Vis-NIR Spectrophotometry
Skin Irritation Test
Viscosity Determination
Antibacterial Activity
Conductivity
Acoustic Impedance
Schematic
Accelerated Stability Test
Evaluation of Images Produced
Visual Inspection
VIS-Spectrophotometry
Transmittance
Antibacterial
Further Evaluation of the Selected Formulation
Conclusions
Materials includedCarbopol
Preparation
Preparation of Ultrasound Gel Formulations
11. Flowchart

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