Preparation and Evaluation of PLGA-based Nanoparticles

Abstract

The current study aimed to increase the stability and therapeutic efficacy of the antitubercular medication rifampicin by reducing or preventing its breakdown in the stomach pH state. Ascorbic acid was used as an antioxidant in the preparation of rifampicin-loaded Poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the investigation. A multistep emulsion process was used to create dig-laden nanoparticles, and different techniques were then used to assess the final product. Ten different kinds of formulations were created for this study. According to the study’s findings, ascorbic acid can increase rifampicin’s stability and bioavailability by reducing its breakdown in acidic pH conditions. The results also show that changing the ascorbic acid concentration makes a statistically important difference in the way the medicine breaks down.