Abstract
Microsponges are the polymeric drug delivery systems composed of porous microspheres. They are tiny sponge like spherical particles that consists of myriad of inter-connecting voids within a non-collapsible structure with a large porous surface. The present work is to formulate and evaluate the Parecoxib Microsponge Hydrogel Sustained Release Tablet. The Microsponges of Parecoxib is prepared by Quasi-emulsion solvent diffusion method using Ethyl cellulose and Eudragit RS100 as polymers and Di-butyl phthalate as Plasticizer. And they are characterized for FTIR studies, production yield, particle size analysis, DSC and SEM. The production yield of formulations was from 77.77 to 82.75. FTIR and DSC studies are revealed that the drug and polymer are compatible with each other during preparation. The average diameter of Microsponge is ranged from 536.9 nm to 489.7.
 Parecoxib Microsponge hydrogel were prepared as sustained release tablets by using sustained release polymers like MCC, Magnesium stearate, Lactose and talc. Preformulation of Microsponge granules were carried out by various parameters and post formulation were carried out by In-vitro dissolution studies, hardness, friability and weight variation tests. Formulation F3 shows good results for the drug release kinetics as controlled release and F6 formulation shows good results for the in-vitro dissolution studies for sustained release.
 Key words: Microsponge hydrogel drug delivery, Parecoxib, Sustained drug release tablets, quasi emulsion solvent diffusion method.
Highlights
The term “Drug Delivery” covers a very extensive range of techniques used to deliver therapeutic agents into the human body
Sustained and controlled drug delivery system helps in constant plasma drug concentration and retards the release rate of drug thereby extending the duration of action
Materials: Parecoxib was procured from Dr J Timmasetty, HOD and Professor, Department of Pharmaceutics, Bapuji College of Pharmacy, Davanagere as gift sample, Ethyl cellulose and Di-butyl-phthalate was supplied from Loba Chemie Pvt
Summary
The term “Drug Delivery” covers a very extensive range of techniques used to deliver therapeutic agents into the human body. Drugs are administered with a main aim of curing patient ailments. Drugs are never administered in their pure form but are converted in a suitable formulation so that its onset and intensity of action as well as total duration of action can be checked. Among the various routes of drug delivery oral route is most widely used route of drug delivery. Sustained Release Drug Delivery System: Among the various routes of drug delivery oral route is most preferred route. N et al, Journal of Biomedical and Pharmaceutical Research minimized. They can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers[1]
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