Preparation and Evaluation of Ofloxacin Sustained Released Gastro Retentive Floating Microspheres

Abstract

Floating microspheres of Ofloxacin were prepared by emulsion cross linking method in which form two phase solution. A total of six formulations were prepared i.e. F1, F2, F3, F4, F5 and F6. Microsphere were evaluated for various rheological properties like bulk density, tapped density, Hausner’s ratio, angle of repose, shows satisfactory results. The prepared microsphere were then evaluated for various physical tests like particle size, drug content, drug entrapment efficiency, swelling index and buoyancy test by using standard procedures. The particle size of all the formulations was ranged between 158.6±0.62 and 205.1±0.42 μm. The drug content and entrapment efficiency was ranged between 18.4±0.48 to 31.1±1.02% and 53.0±1.48 to 76.6±0.94%, respectively. The swelling index and buoyancy were ranged from 79.9±1.42 to 110.6±1.37 and 94.2±0.29 to 121.9±0.19, respectively. The prepared microspheres exhibited good spherical geometry with smooth surface as evidence by scanning electron microscopy. The in vitro release studies exhibited that F3 displayed better sustained effect over a period of 16 hours.