Preparation and evaluation of novel multi-channel orally disintegrating tablets

Abstract

In this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through perforating channels with a special multi-channel mold. A modified sieve method was used in disintegration test as a quick screening tool during formulation evaluation. Moreover, physical properties, in vitro and in vivo disintegration time, dissolution rate and mouthfeel were also evaluated. The results demonstrated that developed multi-channel ODTs had good physical parameters, in vitro/in vivo correlation (IVIVC) of disintegration time and acceptable mouthfeel and dissolution. It also revealed that the presence of channels could accelerate the disintegration of ODTs because the channels could shorten the distance of water penetration and increased the specific surface area, resulting in a significant reduction in disintegration time. Above all, the introduction of novel multi-channel ODTs provided an alternative preparation method for ODTs and achieved good disintegration characteristics.