Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats.

Luiza Madalina Gradinaru,Magdalena Aflori,Mioara Drobota,Maria Butnaru,Coralia Bleotu,Gratiela Gradisteanu Pircalabioru,Maria Spiridon,Mihaela Barbalata-Mandru,Stelian Vlad

doi:10.3390/nano10040754

Luiza Madalina Gradinaru, Magdalena Aflori + Show 7 more

Open Access

https://doi.org/10.3390/nano10040754

Copy DOI

Abstract

A series of nanofibrous composite mats based on polyurethane urea siloxane (PUUS), hydroxypropyl cellulose (HPC) and β-cyclodextrin (β-CD) was prepared using electrospinning technique. PUUS was synthesized by two steps solution polymerization procedure from polytetramethylene ether glycol (PTMEG), dimethylol propionic acid (DMPA), 4,4′-diphenylmethane diisocyanate (MDI) and 1,3-bis-(3-aminopropyl) tetramethyldisiloxane (BATD) as chain extender. Then, the composites were prepared by blending PUUS with HPC or βCD in a ratio of 9:1 (w/w), in 15% dimethylformamide (DMF). The PUUS and PUUS based composite solutions were used for preparation of nanofibrous mats. In order to identify the potential applications, different techniques were used to evaluate the chemical structure (Fourier transform infrared-attenuated total reflectance spectroscopy—FTIR-ATR), morphological structure (Scanning electron microscopy—SEM and Atomic force microscopy—AFM), surface properties (contact angle, dynamic vapors sorption—DVS), mechanical characteristics (tensile tests), thermal (differential scanning calorimetry—DSC) and some preliminary tests for biocompatibility and microbial adhesion.

Highlights

Electrospinning, an electrostatic fiber manufacturing technique, has shown more interest and attention in recent years due to its versatility and potential to be applied in various fields
Solutions of polyurethane urea siloxane (PUUS) blended with hydroxypropyl cellulose (HPC) or β-CD in a ratio of 9:1 (w/w) were prepared in 15% DMF
The properties of the nanofibrous composite based on PUUS and PUUS blended with HPC and β-CD prepared by electrospinning technique, were investigated using a series of characterization methods, including Fourier transform infrared-attenuated total reflectance spectroscopy (FTIR-ATR), scanning electron microscopy (SEM), atomic force microscopy (AFM) and dynamic vapor sorption (DVS)

Summary

Introduction

Electrospinning, an electrostatic fiber manufacturing technique, has shown more interest and attention in recent years due to its versatility and potential to be applied in various fields. This is a relatively simple and convenient technique to produce nanofibers from a wide variety of natural or synthetic polymers, or their blends. Electrospinning is a unique technology that can produce non-woven fibrous materials with fiber diameters ranging from nanometers to microns. Many potential applications are being explored in various fields, due to their large surface area to volume ratio, unique fibrous porosity architecture, interconnected pore structure and malleability to prepare a wide variety of sizes and shapes [2]. Electrospun nanofibers are broadly investigated in biomedical applications, as tissue engineering scaffolds [3,4], wound dressing [5,6], drug delivery [6,7], enzyme immobilization [8,9], etc

Objectives

Methods

Results