Preparation and evaluation of mixed-ligand complexes of Cu (II) and Co (II) with amodiaquine hydrochloride and sulphamethazine

E.A Enemose,B Kpomah,E.E Akporhonor

doi:10.4314/jasem.v22i6.16

Abstract

Cu (ll) and Co (II) complexes of amodiaquine hydrochloride and sulphamethazine (AMOSUF) have been prepared and characterized by elemental analysis, molar conductivity, FTIR and electronic spectroscopy. The compounds are non-electrolyte in solution and the spectra data of the complexes are consistent with 6-coordinate octahedral complexes. It has been found that the two ligands behave as a bidentate forming 1:1:1 stoichiometry and octahedral geometry. Keywords: Amodiaquine hydrochloride, sulphamethazine, Cu (ll), Co (II), metal complexes, spectra

Highlights

The spread of resistant parasite strains to all kinds of drugs is growing high in tropical and sub-tropical regions, including Africa, Asia and part of America (Sachs and Malancy, 2002)
As part of our effort to develop metal based chemotherapy, we presented the preparation and study of mixed ligand complexes of amodiaquine hydrochloride mixed with sulphamethazine (Enemose, et al, 2014)
0.242 g (1 mmol) in 10 mL methanol was added drop wise to 0.278 g (1 mmol) sulfamethazine dissolved in 20 mL methanol which was stirred continuously for 1 h at 40 OC and a 20 mL methanolic solution of 0.356 g (1 mmol) of amodiaquine hydrochloride was slowly added

Summary

Introduction

The spread of resistant parasite strains to all kinds of drugs is growing high in tropical and sub-tropical regions, including Africa, Asia and part of America (Sachs and Malancy, 2002). As part of our effort to develop metal based chemotherapy, we presented the preparation and study of mixed ligand complexes of amodiaquine hydrochloride mixed with sulphamethazine (Enemose, et al, 2014). Synthesis of Copper (II) Complex of Sulfamethazine with Amodiaquine Hydrochloride: Cu (NO3)2 .3H2O

Results

Conclusion