Abstract
In the present work effect of methyl-I²-cyclodextrin (MI²CD) on physical properties and dissolution rate of Irbesartan (IRB) was studied.Based on AL-type ofphase solubility diagram obtained, solid binary systems of the drug with MI²CD were prepared in 1:1 molar ratio by various methods. Complexes were characterized using Differential Scanning Calorimetry and powder X-Ray Diffractometry. It could be concluded that IRB can form inclusion complex with MI²CD. The dissolution profiles of inclusion complexes were compared with those of IRB alone and the physical mixture. The dissolution rate of IRB was increased remarkably by MI²CD inclusion complexation.
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