Abstract
The present investigation was undertaken with the objective of formulating Bufotenin for rapid dissolution of drug and absorption which may produce the rapid onset of action and also to improve the bioavailability of the drug. The fast dissolving strips were prepared by solvent casting method with the selection of HPMC E5, E15, K15, and Microcrystalline Cellulose (MCC), Polyvinyl Alcohol (PVA) as polymers and glycerol as plasticizer. Prepared films were carried out for in vitro evaluation tests such as film thickness, folding endurance, and content uniformity, estimation of moisture content, tensile strength, elongation, disintegration studies and dissolution studies. As per the official limits, film has to release the maximum amount of drug within a minute and it was satisfied by the formulations F1, F4, F7 and F8. It could be concluded from the results that the fast dissolving oral thin film can be a potential dosage form for pediatric and geriatric patients showing effective and faster drug release.
Highlights
Oral route is the most preferred route for the delivery of the drugs till the date due to ease of ingestion, pain avoidance and versatility
Solid oral delivery systems do not require sterile conditions and are, less expensive to manufacture, but oral drug delivery systems still need some advancements to be made because of their drawbacks related to particular class of patients which includes geriatric, paediatric and dysphagic patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms [1,2]
Research and development in the oral drug delivery segment had led to transition of dosage form from simple conventional tablets/ capsules to modified release tablets/capsules to Oral Disintegrating Tablet (ODT) to wafer to the recent development of oral dissolving film, "a thin film that is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity" [5]
Summary
Oral route is the most preferred route for the delivery of the drugs till the date due to ease of ingestion, pain avoidance and versatility (to accommodate various types of drug candidates). Solid oral delivery systems do not require sterile conditions and are, less expensive to manufacture, but oral drug delivery systems still need some advancements to be made because of their drawbacks related to particular class of patients which includes geriatric, paediatric and dysphagic patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms [1,2]. Many paediatric and geriatric patients are unwilling to take solid preparations due to fear of chocking because of tablet appearance and patients experienced difficulty in swallowing tablets. Even fast dissolving tablets there are a fear of choking due to its tablet type appearance. Research and development in the oral drug delivery segment had led to transition of dosage form from simple conventional tablets/ capsules to modified release tablets/capsules to Oral Disintegrating Tablet (ODT) to wafer to the recent development of oral dissolving film, "a thin film that is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity" [5]
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