Abstract
Development of Hydrophobic Carriers based tablets for Sustained Release of VerapamilSarada Anepu, Lohithasu Duppala, P. V. Pratyusha
Highlights
Drotaverine HCl is a benzyl isoquinoline derivative, which causes relaxation of smooth muscle that suppresses pain associated with spasm caused by smooth muscle contraction
The results demonstrated that the prepared drotaverine HCl oral disintegrating tablet (ODT) showed better taste masking meeting the parameters of ODT formulations PF5 > CP9
Drug-polymer mixture was evaluated for taste masking and the optimized ratio was used for the preparation of ODT by direct compression
Summary
Drotaverine HCl is a benzyl isoquinoline derivative, which causes relaxation of smooth muscle that suppresses pain associated with spasm caused by smooth muscle contraction. Drotaverine HCl is sparingly soluble drug having a very bitter taste and patients are reluctant to its taste when the ordinary tablet is kept on the tongue during swallowing. There is a poor patient compliance of using drotaverine HCl which necessitates the masking of its bitter taste during administration and improvement in its solubility and dissolution rate for patient compliance and improved bioavailability. Melt granulation technique was applied in the preparation of lamotrigine using precirol ATO 5 (Pankaj et al, 2010). Earlier workers used polymers like Eudragit E100 and hydroxypropyl cellulose for the preparation of taste masked granules. In the present investigation, it is proposed to prepare taste-masked ODT of drotaverine HCl using the melt granulation technique using compritol and precirol as melt granulating polymers with a disintegration time of less than 1 minute with complete drug release in 30–60 minutes
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