Preparation and evaluation of Diclofenac & Aceclofenac pain relieving gel

Abstract

It is phenyl acetic acid derivative developed as anti-inflammatory agent. It has analgesic anti-inflammatory antipyretic like actions like other NSAIDS. . It is recommended in long term treatment of rheumatoid arthritis, osteoarthritis and enclosing spondylitis. It is also useful acute miscue skeletal disorder post operative pain and dysmenorrhoea Diclofenac sodium gel were developed in seven different formulations) by employing different grades of polymers such as Hpmck4m and Crbopol940. There the various Diclofenac gels are available in market. But the propose gel is formulated with two key ingredients oleoresin, and l linseed oil contribute to anti-inflammatory effect. The formulations were evaluated for various physical parameters, pH spredability, drug release excludability studies drug released mechanisms. Formulation showed maximum drug release of 8 hours and maximum drug. Finally the gel formulations found to be economical and may overcome the draw backs associated with the drug during its absorption. The purpose of the study is to prepare the combination of diclofenac and aceclofenac pain relieving gel. This gel combined form of gel is multifunctional and getting rapid onset of action. And that is to get instant relieve from pain as comparison of plain aceclofenac tablet and plain Diclofenac gel. This formulation is also beneficial for diabetic patient to get cure fast of skin injury and buildup of skin irritation and growth or new epidermis layer of skin in the body.