Abstract
This article discusses a new method to make the crosslinked polyelectrolyte complex (PEC) membranes that has suitable mechanical strength, good solute permeability, hydrophilicity and biocompatibility in dialysis applications. PECs were obtained by mixing two aqueous solutions of water-soluble gelatin and carboxymethyl cellulose (CMC). PEC membranes were prepared under various conditions to determine a suitable mixing ratio of gelatin to CMC, concentration of crosslinking agent and film fablicating conditions, and their properties and permeability of solutes were estimated. Effects of the relative amounts of bound water and free water in the membrane on the solute permeation and mechanical properties were studied. This new PEC membrane not only offers higher solute permeability that the commercial Cuprophane membrane but also shows suitable mechanical strength, non-toxicity and non-pyrogen for dialysis application.
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