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Abstract
In the present study, an interpenetrating polymer network (cross-linked chitosan-polyurethane mix) was successfully prepared. It was found that the mixing of 70% chitosan and 30% polyurethane gave the best results as far as the mechanical properties of the network are concerned. Toxicological evaluation of the network was done in 15 rabbits, and it was found to be pathologically non-toxic. The possible effects of the network on the liver, kidneys, and skeletal muscles of sheep with clean or infected open wounds were studied through the measurement of plasma aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and acid phosphatase. In sheep with clean open wounds that were implanted with the network, the levels of the enzymes were 11.04 0.54; 30.83 1.20; 36.37 1.52; and 5.52 0.37, respectively. In sheep with contaminated wounds, the levels of the enzymes were 11.29 0.30; 38.58 1.16; 38.20 1.21, and 6.31 0.46, respectively. Statistically significant differences were not encountered in the values of alanine aminotransferase, alkaline phosphatase, and acid phosphatase in sheep with clean wounds and those with contaminated wounds. However, the level of aspartate aminotransferase was higher significantly (P
Highlights
In the present study, an interpenetrating polymer network was successfully prepared
As far as measurements of AST, ALT, alkaline phosphatase (ALP), and acid phosphatase (ACP) are concerned, significant differences were not encountered between the values of ALT, ALP, and ACP in sheep with clean wounds and in sheep with contaminated wounds
This finding indicates that the IPN did not have any deleterious effect on the liver, kidneys, and the skeletal muscles of sheep with clean wounds and in those with contaminated wounds
Summary
An interpenetrating polymer network (cross-linked chitosan-polyurethane mix) was successfully prepared. Chitosan has been noted for its application as a film-forming agent in cosmetics, a dyebinder for textiles, a strengthening additive in paper and a hypolipidic material in diets [1, 8]. It has been used extensively as a biomaterial, owing to its immunostimulatory activities, anticoagulant properties, antibacterial and antifungal action and for its action as a promoter of wound healing in the field of surgery [9,10,11,12,13,14,15,16,17,18,19]. The purpose of this study were to prepare a new interpeneterating polymers networks (chitosan-polyurethane meshs) (IPN) and to evaluate the application of these networks in the treatment of experimentally- induced skin injuries in sheep
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