Preparation and Evaluation of Cream Containing Betel Leaf Extract for Removal of Cutaneous Warts

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Abstract: Warts are common skin growths caused by the human papillomavirus (HPV). They can appear on any part of the body but are most commonly found on the hands, feet, and genitals. Warts are usually harmless but can be unsightly or cause discomfort, especially if they are frequent friction or pressure. There are several types of warts, including common warts, plantar warts (on the soles of the feet), genital warts, and flat warts (often found on the face). Creams are semisolid dosage form containing one or more drugs substances dissolved or dispersed in a suitable base. They are emulsion of either W/O, O/W creams are uses for various purposes. Wart removal cream contains some synthetic substances as well as herbal ingredients like betel steam which is having antiviral activity against the human papilloma virus (HPV). Then calcium carbonate and sodium hydroxide slowly absorbed into the skin causing rupturing of the skin cells that contains the wart virus. To prepare wart removal cream sodium hydroxide and calcium carbonate along with the aqueous extract of betel leaf by maceration with the excipients such as stearic acid, glycerin, methyl paraben, distilled water are used. Finally, the cream is evaluated with various parameters such as physical and chemical properties like pH, viscosity, spreadability, texture. As this cream has clove oil which is used as an analgesic to avoid the irritational pain. The pH of the cream is supposed to be basic and around 12-12.5. During the evaluation the pH of the cream was found out to be 12.1. Cream was easily spreadable and it had a pleasant appearance.