Abstract
Magnetic molecularly imprinted polymers (MMIPs), combination of outstanding magnetism with specific selective binding capability for target molecules, have proven to be attractive in separation science and bio-applications. Herein, we proposed the core–shell magnetic molecularly imprinted polymers for food analysis, employing the Fe3O4 particles prepared by co-precipitation protocol as the magnetic core and MMIP film onto the silica layer as the recognition and adsorption of target analytes. The obtained MMIPs materials have been fully characterized by scanning electron microscope (SEM), Fourier transform infrared spectrometer (FT-IR), vibrating sample magnetometer (VSM), and re-binding experiments. Under the optimal conditions, the fabricated Fe3O4@MIPs demonstrated fast adsorption equilibrium, a highly improved imprinting capacity, and excellent specificity to target sterigmatocystin (ST), which have been successfully applied as highly efficient solid-phase extraction materials followed by high-performance liquid chromatography (HPLC) analysis. The MMIP-based solid phase extraction (SPE) method gave linear response in the range of 0.05–5.0 mg·L−1 with a detection limit of 9.1 µg·L−1. Finally, the proposed method was used for the selective isolation and enrichment of ST in food samples with recoveries in the range 80.6–88.7% and the relative standard deviation (RSD) <5.6%.
Highlights
Sterigmatocystin (ST), a carcinogenic mycotoxin, is a secondary metabolite produced mainly by Aspergillus versicolor, Aspergillus flavus, Aspergillus nidulans, fine wrinkles and other fungiAspergillus [1,2,3]
Polymers 2017, 9, 546 liquid chromatography-mass spectrometry (HPLC-MS) has come to be an effective solution, of which the analytical performance highly depends on the adsorption materials [1]
The obtained molecularly imprinted polymers (MMIPs) materials have been fully characterized by scanning electron microscope (SEM), Fourier transform infrared spectrometer (FT-IR), vibrating sample magnetometer (VSM), and re-binding experiments
Summary
Sterigmatocystin (ST), a carcinogenic mycotoxin, is a secondary metabolite produced mainly by Aspergillus versicolor, Aspergillus flavus, Aspergillus nidulans, fine wrinkles and other fungiAspergillus [1,2,3]. ST spreads widely in nature, and could contaminate most food and forage, especially wheat, corn, peanuts and forage, raising great concerns of public society [6,7]. For the quantification of ST in food samples, usually with complex matrix, liquid–liquid extraction or solid phase extraction coupled with high-performance. Polymers 2017, 9, 546 liquid chromatography-mass spectrometry (HPLC-MS) has come to be an effective solution, of which the analytical performance highly depends on the adsorption materials [1]. Imprinted polymers (MIPs) have attracted much attention in the past decades for their high affinity and selectivity [8,9,10]. Molecular imprinting is a well-known method to create recognition sites structurally complementary to the target molecules in a synthetic polymer [11,12,13]
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