Abstract
Interpenetrating polymer network of cross-linked blend microspheres for controlled release of Acebutolol HClP. Ramakrishna, B. Mallikarjuna, A. Chandra Babu, P. Sudhakar, K. Chowdoji Rao, M.C.S. Subha
Highlights
Nanoparticles are defined as a particulate dispersion or solid particles with a size in the range of 10–1,000 nm (Kayser et al, 2005)
The prepared nanoparticles suspension was evaluated for particle size, sedimentation, the interaction between CS and TPP, particles morphology, and antibacterial activity against Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative)
The results showed that among all of the concentrations used, the formulation of 0.25% CS and 0.1% sodium TPP resulted in the smallest particles size with spherical morphology, no sedimentation after centrifugation at 6,000 rpm for 2 hours, and gave the highest antibacterial activity against Staphylococcus aureus and P. aeruginosa
Summary
Nanoparticles are defined as a particulate dispersion or solid particles with a size in the range of 10–1,000 nm (Kayser et al, 2005). Polymeric nanoparticles offer some specific advantages over liposome, for instance, they increase the stability of drug and possess useful controlled release properties (Calvo, et al, 1997a). Nanoparticulate systems show their promise as a potential ideal drug delivery system for poorly soluble, poorly absorbed, and chemically, heat- and photo-labile substances (Florence, 1998). The nanoparticles system offer advantages like increased bioavailability, site-specific drug delivery, sustained release of the Chitosan (CS) is a modified natural carbohydrate polymer prepared by the partial N-deacetylation of chitin, a natural biopolymer derived from crustacean shells such as crabs, shrimps, and lobster (Illum, 1998). CS has a very low toxicity (Nagarajan et al, 2015)
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