Preparation and Evaluation of Chitosan Microspheres Containing Levofloxacin

Abstract

Objectives: The objective of present study was to develop chitosan-based sustained release Levofloxacin microspheres to reduce the dosing frequency. Materials and Methods: The Levofloxacin -loaded microspheres were prepared by emulsification cross-linking method using glutaraldehyde as cross-linking agent. Accurately weighed quantity of Chitosan was dissolved in 1% (v/v) aqueous acetic acid. Results: The percentage yield of the emulsification cross-linking method was determined to be between 74 and 81.5 percent, and the spherical microspheres had particle sizes ranging from 2 m to 200 m. According to the in vitro dissolution analysis of the improved formulation (F2) (table 7.8), when the medication was enclosed in Chitosan microspheres, 95 percent of the formulation was released after 12 hours, demonstrating that the drug is released from the formulation in a controlled way. Conclusions: The percentage of entrapment effectiveness, particle size, and percentage of drug release were significantly impacted by the drug: polymer ratio and GA volume. According to research using scanning electron microscopy (SEM), microspheres were round and had a smooth surface. Nicorandil-loaded chitosan microsphere formulations released their drugs via fickian diffusion.