Abstract
This paper describes the preparation of new bilayered device comprising a drug containing mucoadhesive layer and a drug free backing layer. Bilaminated films were produced by a casting/ solvent evaporation technique. The mucoadhesive layer was composed of mixture of drug and sodium alginate with or without carbopol 934 P, and backing layer was made of ethyl cellulose. The double layer structure design was expected to provide drug delivery in a unidirectional fashion to the mucosa and avoid loss of drug due to wash out with saliva. The fabricated films were subjected to in vitro drug release, in vitro permeation through porcine buccal mucosa. The bilayered films were also evaluated for mucoadhesive strength, mucoadhesive time, folding endurance, hydration studies and tensile strength.
Highlights
This paper describes the preparation of new bilayered device comprising a drug containing mucoadhesive layer and a drug free backing layer
It is well known that the absorption of therapeutic compounds from the oral mucosa provides a direct entry of the drug into the systemic circulation, avoiding the Þrst pass hepatic metabolism and gastrointestinal drug degradation, which is associated with oral administration
From a technological point of view, an ideal buccal dosage form must have three properties; It must maintains its position in the mouth for a few hours, release the drug in a controlled fashion and provide drug release in a unidirectional way towards the mucosa
Summary
March - April 2008 allow drinking and eating or speaking Their administration is restricted to short periods of time and, controlled drug release is not within the scope of such formulations[3]. From a technological point of view, an ideal buccal dosage form must have three properties; It must maintains its position in the mouth for a few hours, release the drug in a controlled fashion and provide drug release in a unidirectional way towards the mucosa. The daily salivary volume secreted in humans is between 0.5 and 2 l4, which is sufÞcient to hydrate oral mucosal dosage forms. This water rich environment of the oral cavity is the main reason behind the selection of hydrophilic polymeric matrices as vehicles for this study
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