Abstract
The present study endeavors in the preparation and characterization of semi crystalline 45S5 bioglass (BG) (SiO2-CaO-P2O5) through sol gel process. Dry press mold technique was used in the preparation porous BG tablets to examine the bioactivity through invitro studies. The synthesized BG powder was subjected to structural, morphological and mechanical characterization and the bioactivity was examined in vitro by immersing the BG tablet in the Simulated Body Fluid (SBF) solution. XRD pattern and the SEM micrographs revealed the semi crystalline nature of BG with spherical morphology. The elemental analysis confirms the presence of vital constituents required for Bone regeneration (Calcium, Phosphorous, Silica, and Sodium). The surface characterization of BG tablet reveals the pores structure of average pore size of 240nm which contributed to the high surface activity resulting in formation of carbonated hydroxy apatite (HCAP) when immersed in SBF. The disintegration studies denoted the stabilization period was after 48 of immersion of BG tablets in SBF solution. The compressive strength measurement of the tablet also reveals the higher mechanical stability.
Highlights
Multiple degenerative, inflammatory joint and bone diseases affected millions of people worldwide
In the Fourier Transformed Infrared (FTIR) spectrum, the two bands at 521 and 539 cm−1 was attributed to PO4 bending vibration and the strong band at 1035cm−1 was caused by PO4 symmetric stretching vibration
The band emerges at 887 and 925cm-1is associated to the Si–O with one non-bridging oxygen (Si–ONBO) per SiO4 tetrahedron which is formed through the presence of the glass network modifier, creating Si-O groups
Summary
Inflammatory joint and bone diseases affected millions of people worldwide. The bioactive nature of these glasses had facilitated to investigate them for implant device in the human body to promote bone regeneration. This Bioactive glasses (BAGs) were discovered in 1969 proved to be an alternative for interfacial bonding of an implant with host tissues. This has led a pathway for using slowly resorbable bioactive glasses as a biomaterials designed exclusively for the repair and replacement of damaged or diseased bones [3]. Bioactive glass were biocompatible with the tissues resulting in formation of Hydroxy apatite (HAP) [4]. Safety of product is very important aspect of the medical field, so various studies were carried out to test the safety for clinical applications [5]
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