Abstract
A novel biodegradable scaffold based on mimetic a natural bone tissue morphology with a porosity gradient structure was prepared in this paper. The result of surface morphology indicated that a graded porous structure was formed in the fabricated scaffold, where the dense layer (0%) was connected with the most porous layer (60%) by a middling porous layer (30%). To evaluate the degradability, graded porous scaffolds compared with homogeneous scaffolds were placed into a Tris-HCl buffer solution (pH = 7.4) for 28 days. It was found that both scaffolds presented the same degradation trend, and the graded porous structure did not change the original degradability of the scaffold. Moreover, the compressive strength of the graded porous scaffold was better than that of conventional homogeneous scaffold with the increase of degradation time, and the graded porous structure can enhanced the mechanical property of the scaffold. These findings suggest that this biodegradable and porosity-graded scaffold may be a new promising scaffold for loaded bone implant.
Highlights
Bone has a functionally graded structure from the surface cortical bone towards the inner cancellous bone (Fig. 1a)
From L3 to L1, the scaffold becomes denser. These results indicate that a graded porous structure is formed in the Calcium polyphosphate (CPP) scaffold
A porosity-graded calcium polyphosphate scaffold was prepared with the aim of simulating the bone tissue morphology
Summary
Bone has a functionally graded structure from the surface cortical bone towards the inner cancellous bone (Fig. 1a). CPP has drawn many researchers’ attention for its outstanding biocompatibility, and for its controllable degradability, excellent mechanical property, and so on (Park et al 2004, Yang et al 2004, Ding et al 2008, Chen et al 2008,Wang et al 2009). All these studies indicated that CPP is an ideal bioceramic with excellent osteoinduction and osteoconduction for bone substitute
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
