Abstract
Ethenzamide (ETZ) solid dispersions were prepared using the sugars sucrose, maltose, galactose and mannitol as carriers by melting and rapid cooling with liquid nitrogen. The physical chararcteristics of these solid dispersions were investigated by powder X-ray diffraction, differential scanning calorimetry and dissolution rate analyses. The dissolution rate of ETZ can be significantly increased by decreasing the crystallinity of ETZ in solid dispersions. The maximum dissolution rate was observed with solid dispersions containing sucrose, and X-ray diffraction analysis suggested that ETZ was present in a totally amorphous state. The physical stability of amorphous sugars in dispersions prepared by rapid cooling was also investigated. Solid dispersions made with amorphous sucrose were more stable than those with other sugars. These results indicated that amorphous sucrose is useful as a carrier for production of solid dispersions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.