Abstract
Nickel(II) complexes with 6-benzylaminopurine (BAP) derivatives, namely 6-(3-chlorobenzylamino)purine (HL1), 6-(4-chlorobenzylamino)purine (HL2) and 6-(4-fluorobenzylamino)purine (HL3), have been prepared and characterized by elemental analyses, i.r., u.v.–v.i.s., ES+ and FAB+ mass spectroscopy, magnetic susceptibility and conductivity measurements, and by thermal analysis. The complexes are: [Ni(L1(H2O)2Cl] · H2O, [Ni(L1)(H2O)-(NO3)] · H2O, [Ni(L2)(H2O)2Cl], [Ni(L2)(H2O)2(NO3)] · H2O, [Ni(HL2)(H2O)Cl2] · EtOH and [Ni(L3)(H2O)2Cl]. They have been tested in vitro for their possible cytotoxic activity against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 (human breast adenocarcinoma) cell lines.
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