Abstract
Objective:To prepare lornoxicam cream and establish a HPLC method for the determination of the content of lornoxicam.Methods:The cream containing 0.2% lornoxicam was prepared by using oil-in-water matrix.HPLC was applied on an Eclipse XDB-Cl8 column with the mobile phase consisting of 0.05mo1/L sodium acetate solution(pH 6.5)-methanol(50∶50).The flow rate was 1ml/min and detection wavelength was 378nm and the column temperature was 30℃.Results:Lornoxicam was of good linearity within the range of 0.01-0.10 mg/ml.The standard curve equation was A =4.85×104 c29.69(r=0.999 5).The recovery rates of low-,middle-and high-concentrations(0.02,0.06,0.10mg/ml)were(99.10±1.37)%,(101.47±0.37)% and(99.25±1.89)%(n=3).The precision of intra-day and inter-day was also good.Conclusion:The prepared lornoxicam cream met with specified quality and the HPLC method for content determination was simple,accurate and reliable.
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