Abstract
The objective of this study was to investigate the potential of water soluble chitosan as a carrier in the preparation of protein‐loaded nanoparticles. Nanoparticles were prepared by ionotropic gelation of water‐soluble chitosan (WSC) with sodium tripolyphosphate (TPP). Bovine serum albumin (BSA) was applied as a model drug. The size and morphology of the nanoparticles were investigated as a function of the preparation conditions. The particles were spherical in shape and had a smooth surface. The size range of the nanoparticles was between 100 and 400 nm. Result of the in vitro studies showed that the WSC nanoparticles enhance and prolong the intestinal absorption of BSA. These results also indicated that WSC nanoparticles were a potential protein delivery system.
Highlights
Peptides and proteins have become the drugs of choice for the treatment of numerous diseases as a result of their incredible selectivity and their ability to provide effective and potent action [1]
The structure of Bovine serum albumin (BSA)-loaded lyophilized nanoparticles was examined by TEM (Tokyo, Japan)
They showed that the particles have a uniform spherical shape and smooth surface (Figure 1(b)), and they are about 150 nm in size (Figure 1(a))
Summary
Peptides and proteins have become the drugs of choice for the treatment of numerous diseases as a result of their incredible selectivity and their ability to provide effective and potent action [1]. They cause fewer side effects and have great potential to cure diseases, rather than merely treat their symptoms. The successful delivery of these protein drugs has been an ongoing topic in the pharmaceutical research for many years. Protein and peptide drugs are poorly absorbed after oral administration because of their susceptibility to enzymatic degradation and their low permeability across the intestinal epithelium. The use of colloidal polymeric particulate delivery systems, mucoadhesive nanoparticles, represents a promising concept [5, 6]
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