Abstract
In recent years, magnetic nanoparticles are increasingly studied and exploited for their potential applications as magnetic resonance imaging (MRI11Magnetic resonance imaging) contrast agents, cancer treatment, targeted therapy, delivery vectors and hyperthermia. Todays, magnetic systems based on polymeric materials such as poly(lactic-co-glycolic acid) (PLGA22Poly(lactic-co-glycolic acid)) have been of special interest for their biomedical applications. In this study, we achieved an effective method for encapsulation of sized-controlled oleic acid-coated superparamagnetic iron oxide (SPIO33Superparamagnetic iron oxide NPs44Nanoparticles) into the PLGA nanospheres via a modified multiple emulsion solvent evaporation method (O1/W1/O2/W255Oil-in-water-in- oil-in-water) resulted in development of the NPs with narrow size distribution and acceptable magnetic properties that are very vital and curtail at targeting and magnetic properties of NPs for both anti-cancer therapy and magnetic resonance imaging studies. The SPIO NPs and SPIO-PLGA nanospheres showed spherical morphology with narrow size distribution of 10nm and 130nm, respectively. SPIO-PLGA nanospheres with high SPIO loading of 18.0% and magnetic properties of 5.9 emu/g were obtained. Furthermore, SPIO-PLGA NPs enhance the contrast of relaxation time (T166Relaxation time)-weighted imaging in tumor site. The prepared SPIO NPs and magnetic PLGA nanosphere could be promising superparamagnetic nanoparticles for simultaneous diagnostic and therapeutic applications.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
