Abstract
Titania microspheres were synthesized using hydrothermal methods to exploit a new liquid chromatography stationary phase. The prepared titania microspheres were approximately 7 μm in diameter, and the particle size distribution was relatively narrow and uniform. Furthermore, the average specific surface area was 276.0 m2·g·1, the average pore volume was approximately 0.25 mL·g·1, and the pore diameter was approximately 35.9 nm for sintering titania microspheres. These parameters indicate that the titania microspheres prepared for this study have excellent surface properties for chromatography. Additionally, columns filled with the titania microspheres were able to separate basic compounds, including benzene, nitrobenzene and o-nitroanisole. It could be proposed that the titania microspheres prepared for this study would be a promising stationary phase for liquid chromatography.
Highlights
High-performance liquid chromatography (HPLC) has been widely accepted as one of the main analytical techniques for organic compounds [1]
This study was intended to test the hypothesis that titania microspheres synthesized by the hydrothermal method could display excellent surface parameters, an ideal mesopore structure, and the narrow size distribution needed for the HPLC stationary phase
After being sintered at 500 ̊C, the diffraction intensity of the titania microspheres sharply increased, and diffraction peaks clearly appeared at 25.32 ̊, 37.88 ̊, 48.11 ̊, 53.94 ̊, and 62.51 ̊, proving that the sintered material belonged to anatase-type of titania
Summary
High-performance liquid chromatography (HPLC) has been widely accepted as one of the main analytical techniques for organic compounds [1]. An increasing number of metal oxide materials have been tested for HPLC column preparation [4] [5]. Titania displays amphoteric ion-exchange properties and has good chemical stability, mechanical strength and enough rigidity [5] [6] to make it an excellent stationary phase material for HPLC columns. This study was intended to test the hypothesis that titania microspheres synthesized by the hydrothermal method could display excellent surface parameters, an ideal mesopore structure, and the narrow size distribution needed for the HPLC stationary phase. To test the chromatographic performance, the prepared titania microspheres were employed as the HPLC stationary phase to separate some basic compounds
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