Abstract
Pulsatile drug delivery systems are time-controlled dosage forms which are designed to release the active pharmaceutical ingredient after a predetermined lag time to synchronize the disease circadian rhythm. A migraine shows circadian rhythm with a marked increase in attacks between 6 a.m. and 8 a.m.
 Sumatriptan is a selective agonist at serotonin (5-Hydroxy tryptamine1 (5-HT1))receptors, is an effective treatment for acute migraine attacks.
 The aim of this work is to prepare time-controlled press-coated tablet with a lag time of 5.45 hrs.
 Six formulas of fast dissolving core tablets and three formulas of press-coated tablets were prepared by using direct compression method using different variables to prepare core tablets which include: different types and concentrations of superdisintegrants While different concentrations of natural and synthetic polymers were utilized in the preparation of press-coated tablets.
 The obtained results showed that formula F4 of core tablet, which contained 25 mg of sumatriptan, 5% w/w sodium starch glycolate and avicel PH 102 as the diluent, was the selected formula that gave the fastest and complete release of sumatriptan. Also, formula C3 of the press-coated tablet, which contained pectin: EC100 mpa.s: HPMCK15M in concentration30mg: 10mg:160mg respectively, was selected as the best coating layer since it gave 5.45 hours lag time.
Highlights
Drug delivery is a term used to describe systems that carry drugs to their targets in the body to ensure its therapeutic effect[1]
It is well known that conventional drug dosage forms give delivery is the most widely utilized route of administration among all the ways that have been instant or fast medication release that provides the determined amount of the drug to the body explored for without any rate control
From above it becomes clear that shifting toward the pulsatile drug delivery system is necessary as it would minimize drawbacks of second-generation dosage forms
Summary
Drug delivery is a term used to describe systems that carry drugs to their targets in the body to ensure its therapeutic effect[1]. Oral drug systemic delivery of drugs via pharmaceutical products of the different dosage form[2]. It is well known that conventional drug dosage forms give delivery is the most widely utilized route of administration among all the ways that have been instant or fast medication release that provides the determined amount of the drug to the body explored for without any rate control. This lack of control leads to a lot of complications inherent to the conventional multiple dosing regimens, e.g., drug accumulation leading to toxicities, variable plasma drug level, and poor compliance. The modified drugrelease dosage forms have a prolonged release of the drug through the longer duration of time which may result in more patient compliance and favorable bioavailability and blood concentrationtime profiles of drugs[4]. From above it becomes clear that shifting toward the pulsatile drug delivery system is necessary as it would minimize drawbacks of second-generation dosage forms
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