Preparation and Characterization of Some Complexes with New (Azo-Schiff base) Ligand and Study of Complex as Anticancer

Abstract

Anew series of transition metal complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), Au(III) and Pt(II) have been preparation and characterization using anew azo-Schiff base ligand derived from schiff base (N1Z,N2Z)-N1,N2-bis(4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine with 5-methyl-imidazole.The structures of the new ligand azo-schiff base and their transition metal complexes are characterized using several techniques,including analysis(C.H.N),molar conductance,magnetic measurements, electronic spectral,IR spectral studies,13CNMR,1HNMR and mass spectra The data show that these complexes have composition of[MLCl2] where M=Co(II),Ni(II), Cu(II),Zn(II),Cd(II) and Hg(II),[ML] Cl3 where M=Au(III) and[ML]Cl2 ,where M=Pt(II).The electronic spectral, and magnetic susceptibility data of the complexes suggest octahedral geometry of all complexes,except the Au(III) and Pt(II) complex suggest a square planar geometry.The IR results demonstrate that the co-ordination sites are the azomethine nitrogen and azo nitrogen atoms of the ligand.The ligand behaves natural tetra dentate manner.The biological screening effect of the Pt(II) complex are tested against human breast cancer cell line MCF-7and normal cells( cell line WRL68).The results show the highest inhibitory effect for complex.