Abstract
Guided tissue regeneration (GTR) is a widely used method in periodontal therapy, which involves the placement of a barrier membrane to exclude migration of epithelium and ensure repopulation of periodontal ligament cells. The objective of this study is to prepare and evaluate a new type of soluble eggshell membrane protein (SEP)/poly (lactic‐co‐glycolic acid) (PLGA) nanofibers using electrospinning method for GTR membrane application. SEP/PLGA nanofibers were successfully prepared with various blending ratios. The morphology, chemical composition, surface wettability, and mechanical properties of the nanofibers were characterized using scanning electron microscopy (SEM), contact angle measurement, Fourier transform‐infrared spectroscopy (FTIR), and a universal testing machine. L‐929 fibroblast cells were used to evaluate the biocompatibility of SEP/PLGA nanofibers and investigate the interaction between cells and nanofibers. Results showed that the SEP/PLGA electrospun membrane was composed of uniform, bead‐free nanofibers, which formed an interconnected porous network structure. Mechanical property of SEP has been greatly improved by the addition of PLGA. The biological study results showed that SEP/PLGA nanofibers could enhance cell attachment, spreading, and proliferation. The study indicated the potential of SEP/PLGA nanofibers for GTR application and provided a basis for future optimization.
Highlights
Periodontal disease that involves the deterioration of toothsupporting structures is one of the most prevalent oral diseases all over the world
To regenerate the damaged periodontal tissue and supporting bone, a surgical approach is widely performed by placing a space-maintaining barrier membrane between the root surface and the gingival flap. This technique, known as guided tissue regeneration (GTR), is based on the exclusion of gingival epithelial cell from the damaged area by using a barrier membrane, allowing the selective repopulation of tissues derived from the periodontal ligament and alveolar bone
These hydrophilic nanofibrous mats had uniform, bead-free and interwoven morphology, which is similar to the extracelluar matrix (ECM) and natural eggshell membrane
Summary
Periodontal disease that involves the deterioration of toothsupporting structures is one of the most prevalent oral diseases all over the world. To regenerate the damaged periodontal tissue and supporting bone, a surgical approach is widely performed by placing a space-maintaining barrier membrane between the root surface and the gingival flap. This technique, known as guided tissue regeneration (GTR), is based on the exclusion of gingival epithelial cell from the damaged area by using a barrier membrane, allowing the selective repopulation of tissues derived from the periodontal ligament and alveolar bone. New approaches are needed to develop a satisfactory barrier membrane which has favorable biocompatibility as well as adequate mechanical strength and space-maintaining ability, in order to fulfill clinically predictable periodontal tissue regeneration
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