Abstract
The aim of the present study was to improve the dissolution rate and oral bioavailability of a poorly water soluble drug, itraconozole (ITR) by its adsorption on a porous calcium silicate (FLR). The drug w as adsorbed on FLR by adsorption method . solid dispersion of various composition were prepared using Porous Calcium Silicate (FLR), Silicic Acid, Colloidal Silica and Silica Gel (Neutral) (2:1, 1:1, 1:2, 1:3, Physical mixture) . C rystallinity of the drug in the solid dispersion was evaluated by differentia l scanning calorimetry and powder X - ray diffraction analysis. Itraconazole was released at a much higher rate from solid dispersion and physical mixture as compared to that as of it r aconazole faster dissolution was exhibited by solid dispersion containing 1:2 ratios of drug and polymer compared to physical mixture and itraconazole . The increase in dissolution rate of the drug may be due to decrease in crystalinity.
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