Preparation and Characterization of Solid Dispersion of Flufenamic Acid by Solvent Evaporation Method

Abstract

The low aqueous solubility of Flufenamic acid (FFA), a Biopharmaceutics Classification System (BCS) II class drug, is a major challenge to overcome its low bioavailability. Poor solubility and low dissolution rate of the poorly aqueous solubility drugs in the aqueous gastrointestinal fluids (6.8 pH) often cause insufficient bioavailability. As for BCS class II drugs, dissolution rate having limiting step, increasing the solubility of drug leads to increases the bioavailability. Therefore, it is important to improve the solubility of flufenamic acid. Several methods such as salt formation, particle size reduction and solid dispersion are available to enhance the solubility of many drugs. In this work, solid dispersion of flufenamic acid with hydrophilic polymer Polyvinylpyrrolidone K 30 (PVP K 30) are produced by solvent evaporation technique. Raw FFA, PVP K-30 and solid dispersion containing FFA and PVP K-30 are characterized by SEM, FTIR. It was observed that morphology of raw FFA was rock like which changed when solid dispersion is formed with PVP K30. The FTIR spectroscopy showed that hydrogen bonding between FFA and PVP occurs in solid dispersion.