Abstract
Patients suffering from cardiovascular disease lack suitable stent. In this study, a new polymeric composite material was prepared by incorporating various concentrations of gamma-glycidoxypropyltrimethoxysilane (GPTMS) into silk fibroin (SF), aiming at achieving a novel composite film with superior mechanical and biological properties, in order to match the requirement of cardiovascular tissue engineering stents. Fourier transform infrared spectroscopy (FTIR) analysis showed that GPTM could promote SF to transform from the original alpha helix and random coil/extension chain conformation to the beta-folded conformation. Tensile experiment indicated tensile strength and breaking elongation of SF/GPTMS hybrid film reach the maximum with 20% GPTMS content. Within a certain range, the water drop contact angle of SF/GPTMS hybrid film is positively correlated with the content of GPTMS. Endothelial cells (ECs) are best grown on hybrid SF/GPTMS hybrid film with 20% GPTMS content.
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