PREPARATION AND CHARACTERIZATION OF SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM CONTAINING ANTI-HYPERTENSIVE DRUG’’

Anukumar E Anukumar E,Yogananda R Yogananda R,Nagaraja T S Nagaraja T S,Bharathi D R Bharathi D R

doi:10.32553/jbpr.v9i4.777

Anukumar E Anukumar E, Yogananda R Yogananda R + Show 2 more

Open Access

https://doi.org/10.32553/jbpr.v9i4.777

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Abstract

The present work is to prepare and characterization of self nano emulsifying drug delivery system containing Anti-hypertensive drug. Losartan is a competitive antagonist and inverse agonist of angiotensin 2 receptor. The SNEDDS is prepared by Sonication method using a components of SPAN 60/Eudragit RS 100 as a surfactant, PVA as a Co-surfactant, Iso propyl alcohol as a solvent and DCM as a co-solvent. The prepared SNEDDS was evaluated for Fourier transform infrared spectroscopy, Surface morphology, particle size, zeta potential, drug entrapment efficiency, visual assessment, self-emulsification time, Robustness to dilution, in-vitro drug release and short term stability studies. The in-vitro drug release data of all the formulations were found to be zero order over a period of 24 h and Formulation F7 shows good results for the drug release kinetics as controlled release. The stability studies data was found that there was no such difference in drug EE and in-vitro drug release.

Highlights

Oral delivery route is that the most convenient route for drug administration to attain desired therapeutic effects and the greatest degree of patient compliance, for chronic condition diseases
Self-nanoemulsifying Drug Delivery system (SNEDDS) is isotropic mixture of oil, natural or synthetic surfactants and co-surfactants that have a ability of forming fine oil in water (O/W) nano-emulsions under mild Agitation followed by aqueous media
Self-Nano emulsifying Drug Delivery System having size vary of globules is a smaller amount than 100nm underneath dispersion of water. numerous strategies for choice of parts and methodology of preparation that square measure mentioned in review of literature, For to attain the SNEDDS

Summary

Introduction

Oral delivery route is that the most convenient route for drug administration to attain desired therapeutic effects and the greatest degree of patient compliance, for chronic condition diseases. Self-nanoemulsifying Drug Delivery system (SNEDDS) is isotropic mixture of oil, natural or synthetic surfactants and co-surfactants that have a ability of forming fine oil in water (O/W) nano-emulsions under mild Agitation followed by aqueous media. Self-Nano emulsifying Drug Delivery System having size vary of globules is a smaller amount than 100nm underneath dispersion of water. SNEDDS square measure ready by trial and error basis to urge smart region forming nanoemulsion. This can be time consuming and needs a bigger range of trails

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Conclusion