Abstract
A sealed heated mixture of ethenzamide (EZ) and porous calcium silicate (Florite[○!R]RE : FR) was prepared by heating the physical mixture in a sealed container. No diffraction peaks due to EZ crystals were observed in the powder X-ray diffraction pattern of the sealed heated mixture (FR : EZ=9 : 1) nor was an endothermic peak observed on the differential scanning calorimetric measurement of the sealed heated mixture (FR : EZ=9 : 1), indicating the amorphization of the EZ crystals caused by heating in a sealed container. The sealed heated mixture with FR showed a greater dissolution rate than EZ crystals or the sealed heated mixture with nonporous calcium silicate (CS). The sealed heating method using porous FR thus provides a promising way of amorphizing EZ crystals without using any solvents and of improving the dissolution rate of EZ.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
