Abstract
An emerging approach in development of nanocarriers for the delivery of hydrophobic anticancer drugs has recently been paid much attention. In this study, a redox-sensitive Heparin-ss-Pluronic F127 (Hep-ss-Plu127) nanogel was fabricated for paclitaxel (PTX) delivery. In the synthetic process, Plu127 was mono-activated by 4-Nitrophenyl chloroformate (NPC) and conjugated with Hep via redox-sensitive disulfide bond of cystamine. The chemical structure of the resulting product was characterized by fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The PTX-loaded Hep-ss-Plu127 nanogels were formed by solvent dialysis method and showed the hydrodynamic diameter of 91.4 ± 0.3 nm, determined by dynamic light scattering (DLS) instrument. Size and morphology of PTX-loaded Hep-ss-Plu127 nanogels were shown to be 104 nm and spherical in shape by transmission electron microscopy (TEM). In addition, PTX was effectively encapsulated into Hep-ss-Plu127 nanogels, which was around 66.2 ± 4.7% for drug loading efficiency and 13.2 ± 0.9% for drug loading content, determined by high performance liquid chromatography (HPLC). Overall, the redox-sensitive Pluronic F127-based nanogel was successfully synthesized and could be an effective nanocarrier that holds a great potential to enhance the redox responsiveness and efficacy for the delivery of PTX in cancer treatment.
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