Abstract
In this study, Pt-doped Bi2MoO6 nanocomposites were prepared by solvothermal and in situ reduction method. We used XRD, UV-Vis spectroscopy, TEM, EDS, and XPS to characterize its chemical properties. Results showed that the Pt-doped Bi2MoO6 nanocomposites had advantages of small size, good dispersion, and wide spectral response range. Then, we tested its biological toxicity and PDT efficiency on HL60 cells. Both pure Bi2MoO6 and Pt-doped Bi2MoO6 nanocomposites showed great biocompatibility after coincubated with leukemia cells for 12 h in the dark. As to PDT efficiency, Pt-doped Bi2MoO6 had a better-inactivated effect than pure Bi2MoO6. Furthermore, the PDT efficiency went up when atomic ratios and concentration increased. While the atomic ratio was 5% and the concentration was 1000 μg/mL, it reached the highest value at 85.2%. At last, we briefly analyzed the photocatalysis mechanism, which demonstrated that it was a potential photosensitizer with high efficiency for treating leukemia.
Highlights
Cancer is a global problem that imposes a growing health and economic burden on human society [1]
No diffraction peak of metal Pt was found in the X-ray powder diffractometer (XRD) pattern of Pt-Doped Bi2MoO6 (Pt-BMO), perhaps this was due to the simple fact that the content of metal Pt was too slight to be detected
The characteristic peak became stronger with the content of Pt increase, which further testified to the successful preparation of Pt-BMO nanocomposites
Summary
Cancer is a global problem that imposes a growing health and economic burden on human society [1]. Photodynamic therapy (PDT) and photothermal therapy (PTT) are becoming promising therapeutic methods for cancer treatment as they have advantages of mild trauma, low toxic, and short treatment period [4,5,6,7,8,9,10]. The mechanism of photodynamic therapy is that the photosensitizers are delivered to tumor through intravenous injection and locally stimulated by the specific wavelength of light. At this time, photosensitizers absorbed lots of energy to produce a series of reactive oxygen species (ROS) and damage tumor cells [11]. How to improve its PDT efficiency remains to a challenging problem for researchers
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